This hermeneutic study explores the esoteric context and complementary ritual discourse of Medieval Haṭha-Yoga and Hindu alchemy, from a Jungian depth psychological perspective. Its comparative approach draws on the essential values, fantasy images, and key concepts of esotericism, to describe a deeper web of relationship within culturally diverse traditions of alchemy. The Tantric vision of immortality is a symbolic expression of the ultimate soteriological value of living-liberation and self-realization. This highest aim is pursued through the corresponding materials and ritual processes of Haṭha-Yoga and Hindu alchemy. Haṭha-Yoga internalized and corporealized Hindu alchemical materials and processes, which sought to create an elixir of immortality. Original Haṭha-Yoga depicts a circular process of psychophysical regeneration, which gives birth to the golden and immortal yogic body. A psychodynamic interpretation is oriented through this spagyric cycle of transformation, through which the yogic body is serially ripened, and the self is realized.