Chronic conditions among older adults are on the rise. While exercise is recommended as a first-line treatment for chronic conditions, there are a number of documented motivators and barriers to physical activity and exercise among older adults. Little research exists on motivators and barriers to exercise among older adults with cardiovascular disease (CVD), type 2 diabetes, and osteoarthritis (OA). The purpose of this study was to determine if there were differences in barriers to exercise and intrinsic motivators between active and sedentary older adults with the chronic conditions of CVD, type 2 diabetes, and/or OA. A secondary purpose of this study was to determine if there were difference in barriers to exercise and intrinsic motivators between older adults with one and two or more chronic conditions. In total, 33 older adults (14 males and 19 females) participated. Independent-samples t-tests were done to compare barriers and intrinsic motivators to exercise between active (n=27) and sedentary older adults (n=6) as well as older adults with one (n=20) and two or more chronic conditions (n=13). This study demonstrated that while the number of conditions did not influence perceived barriers or motivators toward exercise, participation in exercise versus sedentary behavior did influence perceived barriers or motivators toward exercise.