Dissertation/Thesis Abstract

The Impact of Six Weeks of Intermittent Fasting, With and Without Aerobic Exercise, on Serum BDNF in Young Adult Males
by Wallace, Alec W., M.S., California State University, Long Beach, 2020, 97; 27963995
Abstract (Summary)

Brain-derived neurotrophic factor (BDNF) mediates the cognitive effects of aerobic exercise (AE) and is responsive to the metabolic stress imposed by intermittent fasting (IF). Time-restricted feeding (TRF) is an emerging IF-method with limited evidence pertaining to BDNF. This study investigated the impact six weeks of TRF, with (TRF-AE) and without (TRF) AE, has on BDNF in young adult males. Eleven physically inactive participants were randomly assigned into a TRF (n = 4), TRF-AE (n = 4), or control (CON) group (n =3). Resting serum BDNF was quantified before (Day 0) and after (Day 43) the six-week intervention. Body anthropometrics, metabolic blood markers, oxygen consumption, and maximal work rate were also measured. During week 1, TRF fasted 12-hours per day (12:12hr; fast:feed) while TRF-AE also completed three 30-minute bouts on a cycle ergometer at a constant rate of 60 rpm at 60-75% heart rate reserve. Week 2, fasting increased to 14-hours (14:10hr) and exercise duration increased to 45-minutes. In weeks 3-6, fasting increased to 16-hours (16:8hr) and exercise frequency to four days per week. All participants consumed habitual dietary intake ad libitum with TRF and TRF-AE ending caloric intake by 8:00pm daily. There were no significant changes in serum BDNF concentrations after six-weeks. However, TRF reduced fat mass and waist circumference, total cholesterol increased in TRF-AE, and HDL decreased in CON. This study suggests that TRF does not have any significant effect on serum BDNF in healthy young adult males, although the small sample size makes it difficult to draw meaningful conclusions.

Indexing (document details)
Advisor: Escobar, Kurt
Commitee: Cotter, Joshua A., Schick, Evan
School: California State University, Long Beach
Department: Kinesiology
School Location: United States -- California
Source: MAI 82/4(E), Masters Abstracts International
Subjects: Physiology, Nutrition
Keywords: Aerobic exercise, BDNF, Cognition, Intermittent fasting, Time-restricted feeding, Young adult males
Publication Number: 27963995
ISBN: 9798684693915
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