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Dissertation/Thesis Abstract

Association of Cervical Microbiota with Human Papillomavirus Infection and Progression to Cervical Cancer
by Stangis, Mary Margaret, M.S., Wayne State University, 2020, 127; 28087304
Abstract (Summary)

Cervical cancer has been found to be caused by infection with Human Papillomavirus; however, not all women who become infected will develop cancer. While the development of an HPV vaccine has reduced cases, the mortality rate is still over thirty percent. It was investigated whether any common viral or bacterial vaginal pathogens had any effect on risk of developing cervical cancer. Initial results have shown that presence of Mycoplasma species may serve as a biomarker for HPV infection, and that increased Lactobacillus iners within the cervical microbiome may be indicative of a transitional state between healthy and HPV infected, and potentially between HPV infected and precancerous. Trichomonas vaginalis has also been implicated as a potential biomarker for low grade cervical cellular abnormality (ASCUS). Treatment of these infections could be used as a preventative action against development of carcinoma. In addition, routine screenings of HPV infected women for these pathogens may provide earlier warning signs for presence of cancer cells, and function as a tool for risk assessment.

Indexing (document details)
Advisor: Akins, Robert
Commitee: Pellett, Philip, Evans, David
School: Wayne State University
Department: Biochemistry and Molecular Biology
School Location: United States -- Michigan
Source: MAI 82/4(E), Masters Abstracts International
Subjects: Microbiology, Cellular biology, Biochemistry, Oncology
Keywords: Cervical cancer, Cervical microbiome, Human papillomavirus, Vaginal microbiome
Publication Number: 28087304
ISBN: 9798678140944
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