An assessment of a medical-surgical unit established that there were poor communication and teamwork practices. Consequently, an evidence-based practice change was implemented in which TeamSTEPPS 2.0 was utilized to address these weaknesses. Twelve registered nurses were selected through convenience sampling to partake in the project. The nurses completed two questionnaires, the TeamSTEPPS Attitude Questionnaire (T-TAQ) and the TeamSTEPPS Perception Questionnaire (T- TPQ), before and after participating in the program. The implementation of the program encompassed creating the project team to oversee the execution, providing adequate resources, developing budgets and schedules, identifying instructors to teach the TeamSTEPPS program, and evaluating outcomes in eight to ten weeks. The project was made possible through the support of the various stakeholders. Based on the results, the implementation of the TeamSTEPPS program improved perceptions towards communication and teamwork within the unit. The project established that TeamSTEPPS improved nurses’ perceptions and attitudes towards teamwork and communication. In addition to recommending TeamSTEPPS, this manuscript provides strategies that could be utilized to sustain the initiative