Alcohol use disorder (AUD) is one of the most complex disorders to date, and current treatments are often ineffective. The molecular mechanisms are still not well understood enough to develop effective treatment. Scientists have suggested that alternative splicing occurs differently in individuals with alcohol use disorder. The genetic and cellular nature of substance abuse and behavior has long been studied in Drosophila melanogaster (fruit flies). Flies give scientists the ability to precisely alter gene expression and determine the impact on ethanol-induced behavior. Internal ethanol content can be measured to determine how intoxicated animals are upon various exposure durations, similar to a breathalyzer in humans. This research will help determine whether changes in splicing alter naïve sensitivity to ethanol and ethanol-induced behavior. Inevitably, this research will help us better understand how to treat individuals with AUD.
|Commitee:||Luesse, Darron, DiSalvo, Susanne|
|School:||Southern Illinois University at Edwardsville|
|School Location:||United States -- Illinois|
|Source:||MAI 82/3(E), Masters Abstracts International|
|Subjects:||Molecular biology, Genetics|
|Keywords:||Drosophila, Ethanol-induced locomotion, Splicing|
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