Background: Mild Cognitive Impairment (MCI) is defined as a transitional stage between normal aging and Alzheimer’s Disease (AD) in which individuals experience memory impairment, but little functional impairment. However, it appears that functional decline, like cognitive decline, exists on a continuum from healthy aging to dementia onset, and may be readily noticeable by the MCI phase.
Objectives: The study objective was to evaluate the predictive value of functional and cognitive screening and outcome measures, particularly those evaluating memory.
Methods: Participants are a subset of subjects (n = 305) from a large, well characterized sample with/without MCI from a multi-site clinical trial, conducted by the Perelman School of Medicine at the University of Pennsylvania. All participants undergo a battery of functional and cognitive testing.
Results/Discussion: Narrative recall (LM), MMSE, and TICS-M delayed domain subscore are robust predictors of diagnostic outcome. Significant correlations were demonstrated between CDR-SB and TICS-M total score, as well as DSRS and a number of functional and cognitive screening measures. A strong relationship was found between TICS-M total score and DSRS. Demographics had a minimal effect on these relationships in our sample, with the exception of marital status. Cognitive and Functional screening are clearly related in the MCI phase and continue to prove their joint importance in early diagnosis of neurocognitive disorders.
|Commitee:||de Marchena, Ashley, Mechanic-Hamilton, Dawn, Janke, E. Amy|
|School:||University of the Sciences in Philadelphia|
|School Location:||United States -- Pennsylvania|
|Source:||MAI 82/2(E), Masters Abstracts International|
|Subjects:||Cognitive psychology, Psychology|
|Keywords:||Aging, Alzheimers, Cognitive screening, Functional screening, Memory, Mild cognitive impairment|
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