This study examines the experience of infertility among African American couples. Six couples married for 10 or more years were interviewed. At least one member of each couple has been diagnosed with infertility. Three of the couples were able to conceive together following fertility treatment. Two couples were unable to conceive following treatment and decided to adopt. One couple did not seek treatment and have been unable to conceive. A phenomenological research approach was utilized to analyze the data and formulate the results. The personal stories provided by the couples illustrate the profound impact the experience of infertility has had on their lives. The findings demonstrate how infertility can be a traumatizing event that is experienced differently by men and women. The distress of the experience challenges one’s sense of self. The findings also suggest how religion and spirituality played a central role in the lives of the couples, helping them to cope with infertility.