The hydrophobic and the Hofmeister effects play essential roles in the biochemistry of life, but their true nature has bemused researchers for over a century. The use of synthetic hosts have proven to be a useful tool for investigating noncovalent interactions, and have illuminating many aspects of these phenomena on the molecular level. Synthetic hosts with well-defined structures provide a simplified approach to circumvent the ambiguities caused by complex natural systems, and owing their vast utility have found a role in several applications including chemical separations, controlled reactions, and molecular recognition.
Herein is an examination of the complexation behavior of deep-cavity cavitands with a variety of organic and inorganic ion guests, to impart a better understanding of the structural and electronic properties that promote complexation. Calorimetry experiments reveal the thermodynamic contributions of host–guest binding, and in working with computational chemists, the data contributes to the improvement of predictive modeling tools. Anomalous complexation behavior observed during comparative studies between structurally similar hosts have revealed new aspects of the hydrophobic effect. The results have revealed a novel approach for manipulating guest affinity to nonpolar surfaces of hosts in aqueous media.
|Advisor:||Gibb, Bruce C.|
|Commitee:||Pascal, Robert A., Jr., Grayson, Scott M., Schmehl, Russell H.|
|School:||Tulane University School of Science and Engineering|
|School Location:||United States -- Louisiana|
|Source:||DAI-B 82/1(E), Dissertation Abstracts International|
|Subjects:||Organic chemistry, Chemistry|
|Keywords:||Hydrophobic, Hofmeister effect, Host-guest systems|
Copyright in each Dissertation and Thesis is retained by the author. All Rights Reserved
The supplemental file or files you are about to download were provided to ProQuest by the author as part of a
dissertation or thesis. The supplemental files are provided "AS IS" without warranty. ProQuest is not responsible for the
content, format or impact on the supplemental file(s) on our system. in some cases, the file type may be unknown or
may be a .exe file. We recommend caution as you open such files.
Copyright of the original materials contained in the supplemental file is retained by the author and your access to the
supplemental files is subject to the ProQuest Terms and Conditions of use.
Depending on the size of the file(s) you are downloading, the system may take some time to download them. Please be