Globally, Major Depressive Disorder is a chronic illness that impacts more than 300 million people. In the U.S.A, depression accounts for 6.7% of all adults, and 16. 2 million adults have had an episode of Major Depression. About 800,000 individuals ages from 15-29 have lost their lives to suicide every year, and most suffering from depression are non- compliant with their treatment regimen. Cognitive Behavioral Therapy (CBT) is a form of therapy, in which a person learns to change their negative or irrational thought patterns to rational ones. It has been called the golden standard treatment, and is Evidence-Based for MDD. The aim of this Clinical Scholarly Paper (CSP) is to evaluate the effectiveness of an educational intervention on women 18-65 on the alternative treatment to include CBT to reduce the exacerbations of MDD symptoms over a two month- period. Pre-intervention 66 participants were selected through convenience sampling, patients that had never been treated with CBT. Letters went out, and 52 responded. Forty attended the educational intervention. The evaluation of the pre and post-intervention using McNemars Chi-Square test was completed. The result of the chi-squared test was, χ2 (1, N = 40) = 20.05, p <.01. The result of the chi-square test is statistically significant because p < .05, thus rejecting the null hypothesis. Based on the study, there is evidence that education plays a vital role in the decision making and willingness of patients to participate in treatment options.