The main focus of this research was to synthesize [Ru(Phen)2(imPhen)]2+ to which λ-Phage DNA will then be exposed followed by the observation of the compound’s effects on the morphology of the DNA using tapping mode atomic force microscopy (TM-AFM). Previous research from other groups has shown that ruthenium complexes consisting of large planar aromatic ligands are able to effectively bind to DNA via intercalation or other means, thus causing changes in the morphology of the DNA resulting in the inhibition of replication. Due to this being a common mechanism of action of chemotherapeutics and the decreased toxicity associated with ruthenium in comparison to other metal centers, such as platinum, this area of research has been of interest to many research groups.
|Advisor:||Voss, Eric J.|
|Commitee:||Luesse, Sarah, Shaw, Michael|
|School:||Southern Illinois University at Edwardsville|
|School Location:||United States -- Illinois|
|Source:||MAI 81/12(E), Masters Abstracts International|
|Subjects:||Chemistry, Inorganic chemistry|
|Keywords:||Tapping mode atomic force microscopy, DNA, Ruthenium complexes|
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