Sialic acid is a family of carbohydrates derived from neuraminic acid. This sugar is unique in many differing ways from its structure and function. It is located on the end terminus of glycoconjugates on the exterior of cell membranes and is responsible for cell to cell interaction and cell adhesion. Though sialic acid is involved in many different biological roles, one area of focus of this carbohydrate is human milk oligosachharides. HMO’s have been proven to be very beneficial for infants. Herein this work will describe the synthesis of silyl donors and their effects during sialylation.
|Advisor:||De Meo, Cristina|
|Commitee:||Tucker, Kevin, Dixon, Robert|
|School:||Southern Illinois University at Edwardsville|
|School Location:||United States -- Illinois|
|Source:||MAI 81/12(E), Masters Abstracts International|
|Keywords:||Sialylations, Sialic acid, Carbohydrates|
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