Dissertation/Thesis Abstract

Synthesis, Reactivity, and Electrochemical Investigations of Schiff-base Ruthenium Nitrosyl Azides
by Ritter, Sean, M.S., Southern Illinois University at Edwardsville, 2020, 73; 27958016
Abstract (Summary)

Metal nitrosyl compounds are involved in cell signaling via binding of NO to an iron atom resulting in a bent Fe-NO geometry. Notable examples of binding sites include iron hemes. Understanding the redox chemistry is made possible by the attachment of ligands which mimic biological heme sites and is critical for the fields of medicine and bio-inorganic chemistry. Starting with the synthesis of a Ru-model complex for the heme-NO site, Ru(NO)(N3)(t-Bu4-saloph) (t-Bu4saloph = [N,N-Bis(3,5-di-tert-butylsalicylidene)-1,2-diaminobenzene]), we are exploring binding to electrode surfaces through “click” chemistry. The redox chemistry is explored with the aim to compare with the consequences of histidine binding in heme-NO species. Various methodologies towards the introduction of a metal nitrosyl complex to the surface of metal electrodes are investigated. Synthesis of the ruthenium nitrosyl H2(t-Bu4saloph) compounds is discussed. The surface-enhanced Raman spectro-electrochemical analysis of the electrode-bound compounds are described.

Indexing (document details)
Advisor: Shaw, Michael
Commitee:
School: Southern Illinois University at Edwardsville
Department: Chemistry
School Location: United States -- Illinois
Source: MAI 81/12(E), Masters Abstracts International
Source Type: DISSERTATION
Subjects: Chemistry
Keywords: Metal nitrosyl compounds, Cell signaling, Iron hemes
Publication Number: 27958016
ISBN: 9798645498474
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