Periodontitis, a polymicrobial infection and oral disease, affects 1 of 2 Americans over the age of 30. Currently, clinicians prescribe periodontal patients an antimicrobial mouth rinse, Chlorhexidine, to control plaque accumulation on gingiva and tooth structure. However, Chlorhexidine has adverse side effects that patients report which reduces patient compliance. SmartMouth rinse includes 0.05% CPC as an antimicrobial and activated zinc to increase wound healing. In a recent clinical comparison between SmartMouth and Chlorhexidine, SM increased patient compliance while being as effective as CHX in reducing gingival inflammation, bleeding, and plaque accumulation. Studies were performed on PGKs, HGFs, and Epi-Gingival tissues. In LPS-challenged PGKs, wound healing was increased with SM treatment and TLR-2 and TLR-4 expression was significantly reduced for SM and CHX treatment. TLR expression was also significantly reduced in HGFs after SM and CHX treatment. Both SM and CHX treatment reduced IL-1beta secretion LPS-challenged Epi-Gingival tissues, however, SM significantly reduced IL-1beta levels when compared to CHX. SM also significantly reduced IL-8 levels at the 24-hour timepoint when compared to the CHX and media control treatment groups. Ki-67 is expressed in all layers of LPS-challenged Epi-Gingival tissue that was treated with SM. Our studies indicate that SM is a promising mouth rinse for treatment of periodontal disease.
|Advisor:||McCracken, Barbara A.|
|Commitee:||Hubert, Amy, Fowler, Tom|
|School:||Southern Illinois University at Edwardsville|
|School Location:||United States -- Illinois|
|Source:||MAI 81/12(E), Masters Abstracts International|
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