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Die Einflüsse des Ionenkanals Transient Receptor Potential Canonical 4 (TRPC4) auf die Kalzium-Homöostase in Kardiomyozyten
by von Ehrlich-Treuenstätt, Viktor Heinrich, Ph.D., Bayerische Julius-Maximilians-Universitaet Wuerzburg (Germany), 2019, 78; 27766779
Abstract (Summary)
The Transient Receptor Potential Channel Subunit 4 (TRPC4) has been considered as a crucial Ca2+ component in cardiomyocytes promoting structural and functional remodeling in the course of pathological cardiac hypertrophy. Functional properties of TRPC4 are also based on the expression of the TRPC4 splice variants TRPC4α and TRPC4β. Aim of the present study was to analyze cytosolic Ca2+ signals, signaling, hypertrophy and vitality of cardiomyocytes in dependence on the expression level of either TRPC4α or TRPC4β.
| Advisor: | Eder-Negrin , Petra , Maack , C., Schuh, K., Rittner , H. |
| Commitee: | |
| School: | Bayerische Julius-Maximilians-Universitaet Wuerzburg (Germany) |
| School Location: | Germany |
| Source: | DAI-C 81/7(E), Dissertation Abstracts International |
| Source Type: | DISSERTATION |
| Subjects: | Cellular biology |
| Keywords: | Transient Receptor Potential Channel Subunit 4 |
| Publication Number: | 27766779 |
| ISBN: | 9781392559673 |
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