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Dissertation/Thesis Abstract

Impact of Sickle Cell Disease on Executive Functioning in an Adult Population
by Wade, Christina, Psy.D., Pepperdine University, 2020, 117; 27741463
Abstract (Summary)

Objective: Children diagnosed with sickle cell disease (SCD) struggle with executive functions (EF); however, there is a paucity of research on neuropsychological outcomes in adults with SCD. This study aimed to examine differences in EF between adults with SCD and healthy controls.

Participants and Methods: 31 patients with SCD and 34 healthy controls (ages 18-45) participating in an IRB-approved Children’s Hospital Los Angeles (CHLA) study of cerebral blood flow underwent neuropsychological evaluation using the Delis–Kaplan Executive Function System (D-KEFS) Trail Making and Color Word Interference Tests and the Wechsler Adult Intelligence Scale - Fourth Edition (WAIS-IV) Digit Span subtest to assess various aspects of EF. The Wechsler Abbreviated Scale of Intelligence - Second Edition (WASI-II) was administered to estimate general intellectual ability.

Results: There were no significant differences between groups related to age, gender, race, parental education, or general intellectual ability; however, the control group was estimated to have significantly higher current combined annual family income as compared to patients with SCD, x2 (6, N = 65) = 10.87, p = .02. Therefore, income was statistically controlled for during analyses. Both groups performed in the solidly average range across EF measures and no significant differences were noted between groups in working memory, F(1) = .009, p = .93, ηp2 = .000; inhibition, F(1) = .156, p = .03, ηp2 = .03; or cognitive flexibility, F(1) = 3.11, p = .08, ηp2 = .06.

Conclusions: Adults with SCD in this study performed comparably to healthy controls. Early treatment with hydroxyurea to the maximum tolerated dose may improve prognosis and serve as a protective factor against EF deficits in adults with SCD. However, additional research is needed to better understand how treatment protocols influence neuropsychological outcomes in this population.

Indexing (document details)
Advisor: Harrell, Shelly
Commitee: O'Neil, Sharon H., Whitaker, Ashley M., deMayo, Robert
School: Pepperdine University
Department: Psychology
School Location: United States -- California
Source: DAI-B 81/10(E), Dissertation Abstracts International
Subjects: Cognitive psychology, Clinical psychology
Keywords: Cognitive flexibility, Executive functioning, Inhibition, Neuropsychology, Sickle cell disease, Working memory
Publication Number: 27741463
ISBN: 9798607312022
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