The phenomena of alarm fatigue, compassion fatigue, and burnout place nurses, patients, and the health care environment in potentially harmful situations and represent the opposite of the foundation of nursing or caring and compassion satisfaction. The researchable problem was if alarm fatigue should be addressed by health care organizations as mandated by the Joint Commission based on the higher number of alarms that sound in the critical care environment or based on factors related to the nurse that must respond to the alarm. The study purpose was to investigate if the variables of compassion fatigue, burnout, compassion satisfaction, and personal characteristics are associated with alarm fatigue and predict alarm fatigue in critical care nurses. The theoretical framework used to guide the study was Jean Watson’s caring theory. Step-down and intensive care unit nurses from three hospitals in a selected Healthcare Network in Pennsylvania were recruited using convenience sampling. After obtaining Institutional Review Board approval, observation, the ProQOL, and demographic surveys assisted in collecting data on alarm fatigue, compassion fatigue, burnout, compassion satisfaction, and personal characteristics of critical care nurses. The major statistics used to analyze the data included descriptive statistics, point biserial correlation, chi square, Spearman’s rho, and binary logistic regression. The results of this study revealed that alarm fatigue, risk for compassion fatigue, and near risk for burnout were present in the critical care nurse participants. Recommendations for future nursing research on alarm fatigue should consider using a larger sample size, different populations, different variables, or a mixed methodology to further contribute to the nursing knowledge on alarm fatigue. The results of this study provided cues for nurse leaders to devise and implement new strategies and policies to curtail alarm fatigue, compassion fatigue, and burnout.