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Dissertation/Thesis Abstract

Analyse der Osteoklastendifferenzierung auf elektrochemisch abgeschiedenen strontiumdotierten Struvitschichten
by Wimmer, Katharina, Ph.D., Bayerische Julius-Maximilians-Universitaet Wuerzburg (Germany), 2019, 124; 27764449
Abstract (Summary)

Aseptic loosening of implants is still an issue especially for patients with osteoporosis. In order to minimize the risk of implant failure the functionalisation of implant surfaces with strontium is a promising technique. The aim of the present study was to investigate the effect of locally availible strontium on osteoclastic and osteoblastic cells.

Electrochemically assisted deposition was used to provide strontium substituted struvite coatings on titanium surfaces. The strontium concentration ranged from 6 µg to 487 µg per sample. Growth of osteoclastic cells was investigated by the determination of cell number and cellular activity, as well as microscopical and transcriptional level studies. Osteoblasts were studied by determining cell number and cell activity.

A general suppressing influence of strontium was observed on the differentiation and activity of osteoclasts. The most favourable properties were found for the highest strontium concentration under investigation, because additionally cell proliferation and activity of osteoblasts was not significantly affected.

Indexing (document details)
Advisor: Gbureck , Uwe , Blunk , Torsten
School: Bayerische Julius-Maximilians-Universitaet Wuerzburg (Germany)
School Location: Germany
Source: DAI-C 81/6(E), Dissertation Abstracts International
Subjects: Bioengineering
Keywords: Aseptic loosening, Osteoporosis, Strontium
Publication Number: 27764449
ISBN: 9781392708262
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