The nonmedical use of prescription opioid drugs (NMUPOD) is a significant public health problem in the United States. The National Survey of Drug Use and Health indicates that the population at greater risk for NMUPOD is college-aged young adults. However, little data are available on if and how college and university health centers (CUHCs) are responding to NMUPOD. Further, to date, the literature contains little theory-driven research on the topic of screening for NMUPOD by CUHCs. This study examined college and university health center administrators’ attitudes and organizational demographics through the lens of diffusion of innovation and the theory of planned behavior. This study employed a quantitative, nonexperimental correlational research design. Data were collected via an online survey at one time point and analyzed using descriptive statistics and a multiple logistic regression. The population included 1,529 postsecondary institutions from the 50 United States and District of Columbia offering classroom-based options for multiple degree programs and that provide a campus health center derived from the Integrated Postsecondary Education Data System. Of the total institutions solicited, 255 (16.7%) responded and 155 (61%) of the responses were usable. Of the respondents, there were 58 (37.4%) public institutions, 57 (36.8%) private not-for-profit institutions without a religious affiliation, 40 (25.8%) private not-for-profit institutions with a religious affiliation, 77 (49.7%) in a city, and 35 (22.6%) and 43 (27.7%) located in suburban and nonurban environments respectively. Only one of the logistic regression analyses yielded a statistically significant result. The current study and past literature did not support any particular variable as predictive of the status of services to address NMUPOD. This suggested that further study with a larger sample size, fewer variables, or both might have yielded better results.