Dissertation/Thesis Abstract

Cross-linking of Polymannuronate During Spray-drying to Form Microcapsules
by Hudnall, Kevin, M.S., University of California, Davis, 2019, 86; 22622731
Abstract (Summary)

This thesis presents results suggesting that polymannuronate – one of two possible forms of homogeneous alginate, referred to as “polyM” – cross-links when subjected to rapid water loss during spray-drying. This insight is important since the consensus of the field is that polymannuronate does not form cross-links to any significant extent. The research supporting the conclusion that polyMs do not cross-link is typically carried out at non-dynamic conditions (i.e., steady temperatures around 25 °C, constant pressure around 1 atm, and without rapid water loss). Spray-drying conditions are quite different than these standard conditions.

Molecular dynamics studies meant to gain insight into why polymannuronate cross-links during spray-drying were performed. The results of the simulations suggest that rapid water loss increases the attraction between individual polyM chains and Ca2+ ions, between polyM chains and water, and between polyM chains and polyM chains. This increased attraction was seen up until the point of approximately 95% water loss, at which point the trend is reversed. 95% water loss matches the conditions achieved during spray-drying. Additionally, with increased water loss polyM was observed to behave more like polyguluronate – the other form of homogeneous alginate referred to as “polyG” – which is known to cross-link effectively.

The cross-linking of polymannuronate during spray-drying suggests that in forming cross-linked alginate microcapsules (CLAMs) during spray-drying, alginate composition may be a much less significant parameter than previously thought. If so, then the production of microcapsules by spray-drying may be a more cost-effective means of encapsulation than previously thought.

Indexing (document details)
Advisor: Jeoh-Zicari, Tina
Commitee: Fan, Zhiliang, Upadhyaya, Shrinivasa
School: University of California, Davis
Department: Biological Systems Engineering
School Location: United States -- California
Source: MAI 81/4(E), Masters Abstracts International
Subjects: Bioengineering, Engineering
Keywords: alginate, cross-linking, molecular dynamics, polymannuronate
Publication Number: 22622731
ISBN: 9781392703892
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