The generation of cortical dynamics in awake mammals is not yet fully understood. However, it is known that neurons leverage distinct organizational schemes to achieve behavior and cognitive function, and that this precise spatiotemporal organization may go awry in illness. In 2003, a form of scale-free synchrony termed “neuronal avalanches” was first observed by Beggs & Plenz in cultured cortical tissue and later confirmed in rodents, nonhuman primates, and humans. In this dissertation, we draw from monkey and rodent studies to demonstrate that neuronal avalanches capture key features of neural population activity and constitute a robust and stable (e.g. self-organized) indicator of balanced excitation and inhibition in cortical networks. We also show for the first time that neuronal avalanches and oscillations co-exist in frontal cortex of nonhuman primates and identify the avalanche temporal shape as a biomarker predicated upon critical systems theory. Finally, we present progress towards characterizing altered avalanche dynamics in a developmental mouse model for schizophrenia using 2-photon calcium imaging in awake animals.
|Commitee:||Plenz, Dietmar, Losert, Wolfgang, Girvan, Michelle, Jarzynski, Christopher|
|School:||University of Maryland, College Park|
|School Location:||United States -- Maryland|
|Source:||DAI-B 81/4(E), Dissertation Abstracts International|
|Subjects:||Neurosciences, Biophysics, Physics|
|Keywords:||critical brain dynamics, network science, neuronal avalanches, neuronal oscillations, self-organized criticality, systems neuroscience|
Copyright in each Dissertation and Thesis is retained by the author. All Rights Reserved
The supplemental file or files you are about to download were provided to ProQuest by the author as part of a
dissertation or thesis. The supplemental files are provided "AS IS" without warranty. ProQuest is not responsible for the
content, format or impact on the supplemental file(s) on our system. in some cases, the file type may be unknown or
may be a .exe file. We recommend caution as you open such files.
Copyright of the original materials contained in the supplemental file is retained by the author and your access to the
supplemental files is subject to the ProQuest Terms and Conditions of use.
Depending on the size of the file(s) you are downloading, the system may take some time to download them. Please be