Dissertation/Thesis Abstract

pH-Responsive Magnetism of Iron(II) Complexes in Solution and Under Small Confinement as Basis for Smart Contrast Agents
by Nowak, René, Dr.Nat., Universitaet Bayreuth (Germany), 2017, 225; 27600484
Abstract (Summary)

A family of compounds was identified displaying a pH-responsive magnetism in aqueous solution. The underlying mechanism is a proton-driven coordination-induced spin state switch that leads to a paramagnetic relaxation enhancement above a specific proton concentration due to a free coordination site where water molecules can be exchanged. The PD-CISSS was found to be temperature-, concentration- and pH-dependent and to be alterable via ligand substitution. Thereby, the influence of the ligand is mainly determined by the electron donating ability of the methyl groups. The pH-responsiveness is not only limited to complex solutions but can also be observed under small confinement. It was demonstrated that microsized zeolite particles loaded with the presented complexes can show also PD-CISSS effects under removal and addition of water from the intrazeolitic channels. A similar behavior can also be generated in zeolite nanoparticles and the sensitivity of the pH-response is under small confinement still controllable via ligand substitution as it has been observed in solution. The presented PD-CISSS and the amalgamation with biocompatible zeolite nanoparticles is doubtlessly a new impetus for the design of smart contrast agents based on nontoxic iron(II) complexes.

Indexing (document details)
School: Universitaet Bayreuth (Germany)
School Location: Germany
Source: DAI-C 81/4(E), Dissertation Abstracts International
Subjects: Inorganic chemistry, Physical chemistry
Keywords: Paramagnetic relaxation
Publication Number: 27600484
ISBN: 9781687900838
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