Microcephaly is neurological condition within which the brain fails to develop to a normal size resulting in the appearance of a smaller head. Microcephaly often accompanies various neurodevelopmental disorders. The corpus callosum is the largest white matter structure in the brain, comprised primarily of heavily myelinated axons. The corpus callosum connects the left and right hemisphere and allows for communication to occur between hemispheres. Using MRI measurements from a sample of 18 microcephalic patients, I analyzed whether the corpus callosum was impacted as a result of microcephaly. When compared to normocephalic controls, the corpus callosum was generally smaller in relation to overall cerebral hemispheric volume, suggesting that white matter brain tissues may be affected by microcephaly. A deeper understanding of the brain through research on the underlying mechanisms responsible for brain evolution and development is critical to our ability to detect, treat and prevent neurodevelopmental, neurodegenerative and psychiatric disorders.
|Advisor:||Ellis, Meredith A. B.|
|Commitee:||Detwiler, Kate, Vannucci, Robert C.|
|School:||Florida Atlantic University|
|School Location:||United States -- Florida|
|Source:||MAI 81/3(E), Masters Abstracts International|
|Subjects:||Neurosciences, Physical anthropology, Developmental biology|
|Keywords:||Brain, Commissure, Corpus callosum, Development, Microcephaly, MRI|
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