Hardware and physiology impose stringent constraints on the millimeter-scale resolution limits of Magnetic Resonance Imaging (MRI). Diffusion MRI is a technique that can effectively surpass the resolution limit by deriving contrast from micrometer restrictions to water diffusion. This thesis studies time dependence of the diffusion coefficient, D(t), in the body [muscle and prostate], where the specificity towards tissue microanatomy is unlocked through biophysical modeling. Unlike the brain, muscle and prostate have a broad range of length scales facilitating the measurement of a dynamic range of D(t).
Chapter 1 introduces the physical description of the MRI signal and D(t).
Chapter 2 considers the practical/engineering considerations of measuring D(t) on MRI systems.
Chapter 3 demonstrates the measurement of temporal diffusion limits on a fiber phantom.
Chapter 4 measures and models D(t) in muscle tissue, revealing the myofiber diameter, which is a biomarker shown to be sensitive towards both atrophy and hypertrophy.
Chapter 5 measures and models D(t) in prostate cancer, thus revealing stromal cell and luminal diameters. Furthermore, evidence is provided that considerations of D(t) allows for the separation of various prostate cancer grades using MRI.
Chapter 6 reviews the findings of this thesis and considers the potential clinical implications from this work.
|Advisor:||Novikov, Dmitry S., Fieremans, Els|
|Commitee:||Kim, Sungheon G., Sigmund, Eric E., Taouli, Bachir|
|School:||New York University|
|Department:||Basic Medical Science|
|School Location:||United States -- New York|
|Source:||DAI-B 81/2(E), Dissertation Abstracts International|
|Subjects:||Medical imaging, Applied physics|
|Keywords:||Diffusion MRI, Microstructure, Muscle, Prostate cancer|
Copyright in each Dissertation and Thesis is retained by the author. All Rights Reserved
The supplemental file or files you are about to download were provided to ProQuest by the author as part of a
dissertation or thesis. The supplemental files are provided "AS IS" without warranty. ProQuest is not responsible for the
content, format or impact on the supplemental file(s) on our system. in some cases, the file type may be unknown or
may be a .exe file. We recommend caution as you open such files.
Copyright of the original materials contained in the supplemental file is retained by the author and your access to the
supplemental files is subject to the ProQuest Terms and Conditions of use.
Depending on the size of the file(s) you are downloading, the system may take some time to download them. Please be