The constant use of antibiotics in human medical applications, as well as large-scale veterinary and agricultural usage, has led to the presence of trace levels of these chemicals in municipal wastewaters. This presence is increasing human health risks due to the development of antimicrobial resistance in our environmental bacteria. As standard wastewater treatments are not sufficient to quantitatively remove antibiotic activity from waters, the use of advanced oxidation processes is now becoming highly attractive as a final, large-scale, polishing treatment before water release to the environment.
Advanced oxidation processes utilize the generation of the highly oxidizing hydroxyl (•OH) radical to non-selectively and quantitatively destroy remaining organic chemicals in water. This study demonstrates the process of using γ-radiation from a cesium-137 source to produce these •OH radicals for the treatment of different antibiotic solutions in pure water. Using an MTS assay to check for the viability of bacterial cell growth of Staphylococcus aureus and Escherichia coli, the quantification of equivalent hydroxyl radical reactions per antibiotic molecule required to completely deactivate the antibacterial property of these compounds was determined for a number of antibiotic classes. The outcomes of these investigations provides valuable quantitative information for future planned large-scale treatments of antibiotic-contaminated wastewaters.
|Advisor:||Mezyk, Stephen P.|
|Commitee:||Bhandari, Deepali, McAbee, Douglas|
|School:||California State University, Long Beach|
|Department:||Chemistry and Biochemistry|
|School Location:||United States -- California|
|Source:||MAI 81/2(E), Masters Abstracts International|
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