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Dissertation/Thesis Abstract

Human Skeletal Muscle Study Through 2D and 3D Model Design
by Fibben, Kirby Sinclair, M.S., University of California, Irvine, 2019, 30; 13898360
Abstract (Summary)

Through the creation of a 2D and 3D model of human skeletal muscle, structural and functional data can be collected. The initiation mechanisms of Facioscapulohumeral muscular dystrophy’s (FSHD), a genetic dystrophy that causes increasing muscle degeneration, can be identified through the creation of a reproducible model. Here, we share how the details of various facets and properties of the 2D and 3D design affect a human skeletal muscle in vitro. The specifics of how various extracellular matrix play a role in 2D patterning of skeletal muscle is discussed alongside the intricacies of creating a hydrogel based 3D skeletal muscle bundle. While the models have not yet reached optimal design compared to other techniques, this design is close to reaching a state to produce collectible data.

Indexing (document details)
Advisor: Grosberg, Anna
Commitee: Botvinick, Elliot, Yokomori, Kyoko
School: University of California, Irvine
Department: Biomedical Engineering - M.S.
School Location: United States -- California
Source: MAI 81/2(E), Masters Abstracts International
Subjects: Biomedical engineering
Keywords: FSHD, Geltrex, Human skeletal muscle
Publication Number: 13898360
ISBN: 9781085647205
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