Prior research has shown that psychedelic induced ego-dissolution mediates therapeutic outcomes and enhances well-being. The experience of psychedelics has been shown to increase certain mindfulness capacities. A cross-sectional descriptive study was implemented in an online community to examine the relationship between psychedelic induced ego-dissolution and self-compassion in adults who have used psychedelics in the past. This study also investigated the effects of various spiritual and wellness practices engaged in post-psychedelic experience on self-compassion. Respondents were instructed to complete an anonymous questionnaire containing basic demographic questions, questions about past psychedelic use, questions about the spiritual and wellness practices they may engage in and the frequency and duration of those practices, the Ego-Dissolution Inventory, and the Self-Compassion Scale, Short Form. The results showed that there is a moderate positive correlation between psychedelic induced ego-dissolution and self-compassion. Formal sitting meditation, awareness practices, journaling, and somatic or energy practices all significantly impacted the mean scores for self-compassion and ego-dissolution. The role of Social Workers in the field of psychedelic research, policy, and practice is discussed and the importance of continued ego-dissolution research is explored.