The study used secondary data from the 2016 California Health Interview Survey to examine the relationship among Asian American subgroups and health characteristics (e.g. general health, diabetes, hypertension, heart disease, asthma, and smoking) and the various sociodemographic characteristics among the Asian American subgroups (e.g. nativity, gender, age, income, education, and English fluency) and health characteristics. The sample consisted of Chinese (n =465), Filipino (n =326), Japanese (n =489), Korean, (n =326), and Vietnamese (n =388). The study found that there were differences among the Asian American subgroups, such as Vietnamese reported poorer health, Japanese more diabetes and hypertension, and Filipinos reported more obesity. Asian Americans immigrants reported poorer health than their U.S.-born counterparts; men were usually associated with poorer health than women, and health declined with age. Lower income was usually associated with poorer health, diabetes, and hypertension with most subgroups, and poor English was associated with poor health, diabetes, and hypertension with most subgroups. Asian Americans are not a monolithic group; each subgroup of Asian Americans have distinct characteristics and different health needs.