The purpose of the study was to compare the levels of interleukin 6 (IL-6) after an acute bout of resistance exercise (RE) at different intensities and volumes to assess the relationship between RE volume load and plasma IL-6. 10 subjects (seven males and three females) between the ages of 20 and 50 years old participated in three randomized exercise protocols, low intensity-high volume (LIHV; 5 × 20, 45% 1-repetition maximum [1-RM]), moderate intensity-moderate volume (MIMV; 3 × 12, 75% 1-RM), high intensity -high volume (HILV; 2 × 4, 90% 1-RM) each separated between 72 and 96 hours. Capillary blood for IL-6 measurements was drawn immediately pre-exercise, immediately post-exercise, and 1-and 2-hours post-exercise. Results showed no significant differences in the levels of plasma IL-6 for exercise condition or time (p = 0.422 and p = 0.870 respectively), or between condition and time (p = 0.205). In conclusion, RE did not affect plasma levels of IL-6 in any of the three protocols.