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Metal-organic frameworks have a wide range of applications including gas separation, gas capture, catalysis and drug delivery. Due to the in-stent thrombosis of the current drug-eluting stents we propose replacing the toxic polymer with a more biodegradable MOF thin film consisting of MIL-88b. The MIL-88b thin film was formed on functionalized gold through a direct crystallization method and was confirmed using x-ray diffraction (XRD) and Fourier- transform infrared spectroscopy (FTIR). Possible ibuprofen encapsulation and elution was confirmed through FTIR and UV-VIS spectroscopy. The MIL-88b thin film was also formed on medical grade stainless steel to mimic conditions of the current DES. The surface area, using N2 gas isotherm at 770K, of MIL-88b and MIL-53 was compared to validate the favorable porosity for drug delivery application.
Advisor: | Tian, Fangyuan |
Commitee: | Bu, Xianhui, Derakhshan, Shahab |
School: | California State University, Long Beach |
Department: | Chemistry and Biochemistry |
School Location: | United States -- California |
Source: | MAI 58/05M(E), Masters Abstracts International |
Source Type: | DISSERTATION |
Subjects: | Chemistry, Biochemistry |
Keywords: | MIL-88b, Metal-organic frameworks, Stents |
Publication Number: | 10975741 |
ISBN: | 978-1-392-07367-4 |