Dissertation/Thesis Abstract

Using Metal-Organic Framework Film as a Drug-Eluting Stent Coating
by Sua, Andy, M.S., California State University, Long Beach, 2018, 57; 10975741
Abstract (Summary)

Metal-organic frameworks have a wide range of applications including gas separation, gas capture, catalysis and drug delivery. Due to the in-stent thrombosis of the current drug-eluting stents we propose replacing the toxic polymer with a more biodegradable MOF thin film consisting of MIL-88b. The MIL-88b thin film was formed on functionalized gold through a direct crystallization method and was confirmed using x-ray diffraction (XRD) and Fourier- transform infrared spectroscopy (FTIR). Possible ibuprofen encapsulation and elution was confirmed through FTIR and UV-VIS spectroscopy. The MIL-88b thin film was also formed on medical grade stainless steel to mimic conditions of the current DES. The surface area, using N2 gas isotherm at 770K, of MIL-88b and MIL-53 was compared to validate the favorable porosity for drug delivery application.

Indexing (document details)
Advisor: Tian, Fangyuan
Commitee: Bu, Xianhui, Derakhshan, Shahab
School: California State University, Long Beach
Department: Chemistry and Biochemistry
School Location: United States -- California
Source: MAI 58/05M(E), Masters Abstracts International
Source Type: DISSERTATION
Subjects: Chemistry, Biochemistry
Keywords: MIL-88b, Metal-organic frameworks, Stents
Publication Number: 10975741
ISBN: 9781392073674
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