Dissertation/Thesis Abstract

Biophysical and Photobiological Modulations on Cellular Pathways in Alzheimer's Disease
by Yang, Xiaoguang, Ph.D., University of Missouri - Columbia, 2010, 166; 13877179
Abstract (Summary)

The overall goal of this thesis work is to study the effects of biomodulations on Alzheimer's disease (AD) related cellular pathways, using biophysical and photobiological methods, including secretory phospholipase A2, various fatty acids treatments and low energy light irradiation. By increasing membrane fluidity in neuronal cells, secretory phospholipase A2 and unsaturated fatty acids with 4 or more double bonds are able to increase the secretion of neuroprotective and neurotrophic α-secretase-cleaved soluble APP (sAPPα). Low energy laser at 632.8 nm is able to suppress amyloid-β peptide (Aβ)-induced oxidative and inflammatory responses in primary astrocytes, suggesting it has neuroprotective effects against oxidative stress and inflammation in AD. This thesis work provides insights into potential therapeutic treatments and prevention of AD.

Indexing (document details)
Advisor: Lee, James C-M.
Commitee: Lee, James C-M., Sun, Grace Y., Tan, Jinglu, Yao, Gang
School: University of Missouri - Columbia
Department: Biological Engineering
School Location: United States -- Missouri
Source: DAI-B 80/08(E), Dissertation Abstracts International
Subjects: Biomedical engineering
Keywords: Alzheimer's disease, App processing, Fatty acids, Low energy laser, Membrane fluidity, sPLA2
Publication Number: 13877179
ISBN: 9781392055984
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