Background: Depression is common among people living with HIV (PLHIV). Studies on the relationship between depression and use of antiretroviral therapy (ART) are inconclusive.
Methods: A meta-analysis was conducted to summarize the relationship between depression and ART use in PLHIV. Ten electronic databases and multiple websites of conferences and dissertations were searched. A random effects meta-analysis was performed to pool the odds ratio estimates from eligible studies. Subgroup analyses and meta-regression were conducted for moderator analysis. Sensitivity analysis was performed to find influential studies. A funnel plot, the Egger test, and the trim and fill analysis were used to detect publication bias.
Results: The pooled sample size was 7,375 with the inclusion of nine eligible studies. The pooled prevalence of depression was 41% (95% confidence interval [CI]: 29%-53%). The pooled ART use rate was 52% (95% CI: 37%-67%). PLHIV with depression were 14% less likely (pooled odds ratio [OR]: 0.86; 95% CI: 0.71- 1.05) to use ART than those without depression. Subgroup analyses showed that depression was significantly associated with no ART use (pooled OR: 0.84; 95% CI: 0.71-0.99) among studies with a prospective study design (11 populations from 9 studies). Moderator analyses did not show any statistically significant effects. The publication bias analyses showed no evidence of small study effects.
Conclusions: Depression was associated with non-use of ART among PLHIV. Studies are needed to explore this association in other countries with varied populations, as most published studies have been conducted in the United States.
|Advisor:||Vermund, Sten H.|
|Commitee:||Amico, K. Rivet, Kipp, Aarom M., Qian, Han-Zhu, Shepherd, Bryan E., Vermund, Sten H.|
|School Location:||United States -- Tennessee|
|Source:||DAI-B 80/07/(E), Dissertation Abstracts International|
|Subjects:||Health sciences, Environmental science|
|Keywords:||Adherence, Antiretroviral therapy, Depression/anxiety, HIV, Initiation, Men who have sex with men|
Copyright in each Dissertation and Thesis is retained by the author. All Rights Reserved
The supplemental file or files you are about to download were provided to ProQuest by the author as part of a
dissertation or thesis. The supplemental files are provided "AS IS" without warranty. ProQuest is not responsible for the
content, format or impact on the supplemental file(s) on our system. in some cases, the file type may be unknown or
may be a .exe file. We recommend caution as you open such files.
Copyright of the original materials contained in the supplemental file is retained by the author and your access to the
supplemental files is subject to the ProQuest Terms and Conditions of use.
Depending on the size of the file(s) you are downloading, the system may take some time to download them. Please be