Sympathetic nerves are important for renal physiology and sepsis pathophysiology. A recent study showed sprouting of sympathetic nerves in spleen of septic mice. This study was done to test if renal sprouting of sympathetic nerves also happens and to investigate renal morphology in septic mice. Cecal ligation and puncture (CLP) was used to induce sepsis and kidneys were removed for evaluation. Bowman’s space was diminished with cortical bubble cells present suggestive of acute renal pathology, however, renal function was unchanged. Acute sepsis did not affect either renal sympathetic innervation or non-neuronal cholinergic cells. Mouse kidneys had more epinephrine (EPI) than norepinephrine (NE) in both groups. This is most likely due to uptake of epinephrine by renal sympathetic nerves and may have no correlation with sepsis. In conclusion, septic mice showed minor renal pathology and no evidence of acute sympathetic nerve sprouting. Further studies are needed to understand the mechanism and consequences of elevated EPI in mice kidney.
|Advisor:||Hoover, Donald B.|
|Commitee:||Hoover, Donald, Jones, Thomas, Ozment, Tammy|
|School:||East Tennessee State University|
|School Location:||United States -- Tennessee|
|Source:||MAI 58/04M(E), Masters Abstracts International|
|Subjects:||Cellular biology, Systematic biology|
|Keywords:||Cholinergic, Kidney, Mice, Non-neuronal, Sepsis, Sympathetic|
Copyright in each Dissertation and Thesis is retained by the author. All Rights Reserved
The supplemental file or files you are about to download were provided to ProQuest by the author as part of a
dissertation or thesis. The supplemental files are provided "AS IS" without warranty. ProQuest is not responsible for the
content, format or impact on the supplemental file(s) on our system. in some cases, the file type may be unknown or
may be a .exe file. We recommend caution as you open such files.
Copyright of the original materials contained in the supplemental file is retained by the author and your access to the
supplemental files is subject to the ProQuest Terms and Conditions of use.
Depending on the size of the file(s) you are downloading, the system may take some time to download them. Please be