Dissertation/Thesis Abstract

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Effects of Acute Sepsis on Renal Structure and Sympathetic Innervation in Mice
by Alkhateeb, Tuqa, M.S., East Tennessee State University, 2017, 55; 13830151
Abstract (Summary)

Sympathetic nerves are important for renal physiology and sepsis pathophysiology. A recent study showed sprouting of sympathetic nerves in spleen of septic mice. This study was done to test if renal sprouting of sympathetic nerves also happens and to investigate renal morphology in septic mice. Cecal ligation and puncture (CLP) was used to induce sepsis and kidneys were removed for evaluation. Bowman’s space was diminished with cortical bubble cells present suggestive of acute renal pathology, however, renal function was unchanged. Acute sepsis did not affect either renal sympathetic innervation or non-neuronal cholinergic cells. Mouse kidneys had more epinephrine (EPI) than norepinephrine (NE) in both groups. This is most likely due to uptake of epinephrine by renal sympathetic nerves and may have no correlation with sepsis. In conclusion, septic mice showed minor renal pathology and no evidence of acute sympathetic nerve sprouting. Further studies are needed to understand the mechanism and consequences of elevated EPI in mice kidney.

Indexing (document details)
Advisor: Hoover, Donald B.
Commitee: Hoover, Donald, Jones, Thomas, Ozment, Tammy
School: East Tennessee State University
Department: Biological Sciences
School Location: United States -- Tennessee
Source: MAI 58/04M(E), Masters Abstracts International
Source Type: DISSERTATION
Subjects: Cellular biology, Systematic biology
Keywords: Cholinergic, Kidney, Mice, Non-neuronal, Sepsis, Sympathetic
Publication Number: 13830151
ISBN: 9780438790858
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