Dissertation/Thesis Abstract

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The Development and Application of the α-Alkenylation of Enolates and Related Multicomponent Reactions
by Grigalunas, Michael John, Ph.D., University of Notre Dame, 2017, 612; 13836188
Abstract (Summary)

The improvement and discovery of new chemical reactions can provide a way to more rapidly access fine chemicals. These reactions are especially desirable if they can be conducted catalytically and/or in a multicomponent fashion. Herein, different reactions based on transition metal-catalyzed α-alkenylation of enolate couplings were developed utilizing either two- or three-components. Both a Pd- and a Ni-catalyzed α- alkenylation procedures that operate under mild conditions were established. The Pd-catalyzed procedure was used as a platform to develop new multicomponent reactions to rapidly access complex molecules from readily available starting materials. The developed reactions were then applied to synthesize potential therapeutics for the treatment of Niemann-Pick Type C disease and towards the synthesis of a fluorescent cholesterol mimic.

Indexing (document details)
Advisor: Helquist, Paul, Wiest, Olaf
Commitee: Helquist, Paul, Iluc, Vlad, Norrby, Perola, Taylor, Richard, Wiest, Olaf
School: University of Notre Dame
Department: Chemistry and Biochemistry
School Location: United States -- Indiana
Source: DAI-B 80/06(E), Dissertation Abstracts International
Source Type: DISSERTATION
Subjects: Organic chemistry
Keywords: Multicomponent reactions
Publication Number: 13836188
ISBN: 978-0-438-83321-0
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