The improvement and discovery of new chemical reactions can provide a way to more rapidly access fine chemicals. These reactions are especially desirable if they can be conducted catalytically and/or in a multicomponent fashion. Herein, different reactions based on transition metal-catalyzed α-alkenylation of enolate couplings were developed utilizing either two- or three-components. Both a Pd- and a Ni-catalyzed α- alkenylation procedures that operate under mild conditions were established. The Pd-catalyzed procedure was used as a platform to develop new multicomponent reactions to rapidly access complex molecules from readily available starting materials. The developed reactions were then applied to synthesize potential therapeutics for the treatment of Niemann-Pick Type C disease and towards the synthesis of a fluorescent cholesterol mimic.
|Advisor:||Helquist, Paul, Wiest, Olaf|
|Commitee:||Helquist, Paul, Iluc, Vlad, Norrby, Perola, Taylor, Richard, Wiest, Olaf|
|School:||University of Notre Dame|
|Department:||Chemistry and Biochemistry|
|School Location:||United States -- Indiana|
|Source:||DAI-B 80/06(E), Dissertation Abstracts International|
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