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Dissertation/Thesis Abstract

Mouse Models of Prostate Cancer Bone Metastasis: Therapies and Mechanisms
by Cunningham, David M., Ph.D., Tulane University, 2018, 104; 10787826
Abstract (Summary)

High incidence of prostate cancer is a major public health issue in the Western world, and bone metastasis is one of the final clinical consequences of prostate cancer progression. In an effort to understanding the molecular pathogenesis of this disease, numerous cell models have been developed, arising mostly from patient biopsies. The introduction of the genetically engineered mouse in biomedical research has allowed the development of murine models for the investigation of tumorigenic and metastatic processes. Current challenges to the field include lack of an animal model that faithfully recapitulates bone metastasis of prostate cancer.

Indexing (document details)
Advisor: You, Zongbing
Commitee: Abdel-Mageed, Asim, Dong, Yan, Flemington, Erik, Rowan, Brian
School: Tulane University
Department: Structural and Cellular Biology
School Location: United States -- Louisiana
Source: DAI-B 80/04(E), Dissertation Abstracts International
Subjects: Molecular biology, Cellular biology, Health sciences
Keywords: Bone metastasis, Interleukin-17, Monomethyl auristatin E phosphate, Mouse model, Prostate cancer, Therapeutic
Publication Number: 10787826
ISBN: 978-0-438-74339-7
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