High incidence of prostate cancer is a major public health issue in the Western world, and bone metastasis is one of the final clinical consequences of prostate cancer progression. In an effort to understanding the molecular pathogenesis of this disease, numerous cell models have been developed, arising mostly from patient biopsies. The introduction of the genetically engineered mouse in biomedical research has allowed the development of murine models for the investigation of tumorigenic and metastatic processes. Current challenges to the field include lack of an animal model that faithfully recapitulates bone metastasis of prostate cancer.
|Commitee:||Abdel-Mageed, Asim, Dong, Yan, Flemington, Erik, Rowan, Brian|
|Department:||Structural and Cellular Biology|
|School Location:||United States -- Louisiana|
|Source:||DAI-B 80/04(E), Dissertation Abstracts International|
|Subjects:||Molecular biology, Cellular biology, Health sciences|
|Keywords:||Bone metastasis, Interleukin-17, Monomethyl auristatin E phosphate, Mouse model, Prostate cancer, Therapeutic|
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