The sympathetic nervous system (SNS) is the main control center for the neurogenic regulation of blood pressure and is affected in fructose induced hypertension. The brain is by far the greatest consuming and energy demanding organ in the body which has the ability to metabolize and generate fructose but with consequences. Diets high in salt and fructose enter the body and eventually crosses the blood brain barrier where it exerts its effects on SNS signaling. The aim of this thesis is to determine the connection between fructose and hypertension along with the detrimental effects of fructose within the brain. Here we test the hypothesis that a high salt combined with a high fructose diet contributes to hypertension by increased cerebral spinal fluid (CSF) sodium concentrations which alter key neuronal signaling mechanisms.
|Advisor:||Shan, Zhiying J.|
|Commitee:||Chen, Qing-Hui, Zhao, Feng|
|School:||Michigan Technological University|
|School Location:||United States -- Michigan|
|Source:||MAI 58/02M(E), Masters Abstracts International|
|Keywords:||Diet, Fructose, GLUT5, High salt, Hypertension, Paraventricular nucleus|
Copyright in each Dissertation and Thesis is retained by the author. All Rights Reserved
The supplemental file or files you are about to download were provided to ProQuest by the author as part of a
dissertation or thesis. The supplemental files are provided "AS IS" without warranty. ProQuest is not responsible for the
content, format or impact on the supplemental file(s) on our system. in some cases, the file type may be unknown or
may be a .exe file. We recommend caution as you open such files.
Copyright of the original materials contained in the supplemental file is retained by the author and your access to the
supplemental files is subject to the ProQuest Terms and Conditions of use.
Depending on the size of the file(s) you are downloading, the system may take some time to download them. Please be