Dissertation/Thesis Abstract

Exploring Structure and Function Relationships of the Solute Carrier Protein Family in Disease
by Keathley, Russell Hudson, M.S., Icahn School of Medicine at Mount Sinai, 2018, 51; 10931576
Abstract (Summary)

The solute carrier family (“SLC”) is a diverse group of membrane transporter proteins expressed ubiquitously throughout the human body. SLC members have been heavily implicated in Mendelian disease, and play an active role in the pathogenesis of many cancers. Further, several members of the SLC family have ligands and/or precise functions that have yet to be elucidated. As such, examining the structure and function relationships of this family can have significant implication in the study and drug design of serious disease. We explored these structure and function relationships in three specific SLC members, with the goal of applying a homology modeling approach to both tool compound discovery and the examination of disease mechanisms. This study highlights the importance of homology modeling both in the exploration of the role SLC members play in human disease, and in human health overall.

Indexing (document details)
Advisor: Schlessinger, Avner
Commitee: Blitzer, Robet, Hanss, Basil, Schlessinger, Avner
School: Icahn School of Medicine at Mount Sinai
Department: Pharmacology and System Biology
School Location: United States -- New York
Source: MAI 58/02M(E), Masters Abstracts International
Subjects: Computational chemistry, Pharmacology
Publication Number: 10931576
ISBN: 978-0-438-39588-6
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