The solute carrier family (“SLC”) is a diverse group of membrane transporter proteins expressed ubiquitously throughout the human body. SLC members have been heavily implicated in Mendelian disease, and play an active role in the pathogenesis of many cancers. Further, several members of the SLC family have ligands and/or precise functions that have yet to be elucidated. As such, examining the structure and function relationships of this family can have significant implication in the study and drug design of serious disease. We explored these structure and function relationships in three specific SLC members, with the goal of applying a homology modeling approach to both tool compound discovery and the examination of disease mechanisms. This study highlights the importance of homology modeling both in the exploration of the role SLC members play in human disease, and in human health overall.
|Commitee:||Blitzer, Robet, Hanss, Basil, Schlessinger, Avner|
|School:||Icahn School of Medicine at Mount Sinai|
|Department:||Pharmacology and System Biology|
|School Location:||United States -- New York|
|Source:||MAI 58/02M(E), Masters Abstracts International|
|Subjects:||Computational chemistry, Pharmacology|
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