In this study, we showed that exposure to UV light has detrimental effects on planarian flatworms, including phenotypes characteristic of stem cell loss, and that knockdown of planarian homologs of XP genes generally increases their sensitivity to UV damage. Planarians are an extreme natural example of renewal capabilities, just as the Xeroderma pigmentosum disease is an extreme exemplification of DNA repair failure. Our work sets the stage for further study of Xeroderma pigmentosum in the planarian model system. Due to the extraordinary capacity of this organisms to regenerate, the genetic tools applicable for their research, and the ease with which experiments can be performed on planarians, there is great potential for further investigation of the mechanism of nucleotide excision repair and its links to XP symptoms in this system.
|Commitee:||McCracken, Vance, Williams, Jason|
|School:||Southern Illinois University at Edwardsville|
|School Location:||United States -- Illinois|
|Source:||MAI 58/01M(E), Masters Abstracts International|
|Subjects:||Molecular biology, Genetics, Cellular biology|
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