Dissertation/Thesis Abstract

Characterization of Planarian Homologs of Human Xeroderma Pigmentosum Genes
by Villarreal Rodriguez, Lucero J., M.S., Southern Illinois University at Edwardsville, 2018, 76; 10844363
Abstract (Summary)

In this study, we showed that exposure to UV light has detrimental effects on planarian flatworms, including phenotypes characteristic of stem cell loss, and that knockdown of planarian homologs of XP genes generally increases their sensitivity to UV damage. Planarians are an extreme natural example of renewal capabilities, just as the Xeroderma pigmentosum disease is an extreme exemplification of DNA repair failure. Our work sets the stage for further study of Xeroderma pigmentosum in the planarian model system. Due to the extraordinary capacity of this organisms to regenerate, the genetic tools applicable for their research, and the ease with which experiments can be performed on planarians, there is great potential for further investigation of the mechanism of nucleotide excision repair and its links to XP symptoms in this system.

Indexing (document details)
Advisor: Hubert, Amy
Commitee: McCracken, Vance, Williams, Jason
School: Southern Illinois University at Edwardsville
Department: Biological Sciences
School Location: United States -- Illinois
Source: MAI 58/01M(E), Masters Abstracts International
Source Type: DISSERTATION
Subjects: Molecular biology, Genetics, Cellular biology
Keywords:
Publication Number: 10844363
ISBN: 9780438360334
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