This thesis explores the intersection between ego consciousness and individuation as it relates to mystical experience occasioned by psychedelics, particularly the molecule 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT). A brief history and description of the chemical nature of 5-MeO-DMT is offered. Synthesizing a depth psychological understanding and a psychedelic perspective with current studies on cognitive neuroscience and neurophilosophical ideas, this thesis uses a hermeneutic methodological approach in conjunction with an alchemical hermeneutic methodological approach consisting of the author’s own experiences to illustrate the dialogue possible between conscious and unconscious. The exploration between conscious and the unconscious includes three personal experiences with 5-MeO-DMT in a religious/ceremonial setting, as well as dreams, and synchronicities as the framework for an analysis of personal transformation. Speculations on clinical implications and applications are provided.