Dissertation/Thesis Abstract

Molecular Evolution of Pregnancy
by Mika, Katelyn Marie, Ph.D., The University of Chicago, 2018, 109; 10817198
Abstract (Summary)

Unraveling the molecular etiology of a novel phenotype is still a major challenge. Mammalian pregnancy, a novel phenotype, preserves its stepwise evolution in extant species, which gives us additional tools to use to begin to unravel its evolution. Within this thesis, the evolution of three components of pregnancy are explored- the regulation of TAP2 expression, the regulation of HLA-F expression, and the possible role of transposable elements in rewiring the regulatory networks underlying major gene expression shifts at the maternal-fetal interface.

Indexing (document details)
Advisor: Lynch, Vincent
Commitee: Novembre, John, Ober, Carole, Thornton, Joe
School: The University of Chicago
Department: Human Genetics
School Location: United States -- Illinois
Source: DAI-B 79/11(E), Dissertation Abstracts International
Source Type: DISSERTATION
Subjects: Molecular biology, Genetics, Evolution and Development
Keywords: Evolution, Gene regulation, Pregnancy, SRA - BLAST, TAP2, Transposable elements
Publication Number: 10817198
ISBN: 9780438088443
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