Dissertation/Thesis Abstract

Regulation of Twin Arginine Translocation System in Salmonella enterica Typhimurium
by Kays, Gary S., M.S., Southeast Missouri State University, 2018, 71; 10790406
Abstract (Summary)

Salmonella enterica serovar Typhimurium (S. Typhimurium) is a pathogenic gram negative bacteria. Secretion systems are necessary for cell processes and for virulence. The Twin Arginine Translocation system (Tat) translocates folded proteins through the cytoplasmic membrane into the periplasmic space. Regulation of Tat in S. Typhimurium has not been elucidated. In E. coli, regulation of Tat has been briefly studied, but was thought to be constitutively expressed. This study provides evidence that in S. Typhimurium, tat expression is upregulated when grown in bile salts and indole, and possibly downregulated when grown in elevated temperatures. Additionally, evidence is presented that the regulation induced by indole occurs through action of the σE, PhoPQ, and CpxA/R regulatory systems. The regulation of tat induce by bile is not through σE, PhoPQ, BarA/SirA, BaeS/R or CpxA/R.

Indexing (document details)
Advisor: Ellermeier, Jeremy
Commitee: Lilly, Walt, Ragain, Christina
School: Southeast Missouri State University
Department: College of Science, Technology, and Agriculture
School Location: United States -- Missouri
Source: MAI 57/06M(E), Masters Abstracts International
Source Type: DISSERTATION
Subjects: Biology
Keywords: Bacteria, Salmonella, Secretion systems, Tat
Publication Number: 10790406
ISBN: 9780438000698
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