Respiratory syncytial virus (RSV) is the most common viral cause of lower respiratory tract disease in infants and children. The incidence of RSV infection worldwide is high among infants, children, immunosuppressed adults, and the elderly. Despite the fact that nearly all individuals are infected by the age of two, complete immunological protection is never attained and re-infections are common throughout life. Currently, there is no licensed vaccine or effective therapy against RSV, and vaccine development has been hampered by the legacy of enhanced lung disease observed during trials of a formalin-inactivated, alum precipitated whole virus RSV (FIRSV) formulation. Other obstacles in designing an effective vaccine against RSV include its weak immunogenicity and the ability of viral proteins to induce an allergic-type memory response. Since the upper respiratory tract is never effectively protected against RSV infection, of particular need are vaccines that induce a sterilizing mucosal immune response. The experiments detailed herein demonstrate poor stimulation of innate defenses following RSV infection and test the hypothesis that the inability to induce a robust innate response following RSV infection hinders the development of a protective adaptive immune response against this virus and may therefore contribute to the high frequency of re-infections throughout life.
|School:||The Ohio State University|
|School Location:||United States -- Ohio|
|Source:||DAI-B 79/09(E), Dissertation Abstracts International|
|Keywords:||Interferon, Recombinant, Respiratory, Vaccine|
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