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Dissertation/Thesis Abstract

C/EBP Delta Expression and Function in Prostate Cancer Biology
by Sanford, Daniel C., Ph.D., The Ohio State University, 2006, 181; 10835721
Abstract (Summary)

Prostate cancer is the most common cancer among men and the second leading cause of cancer-related mortality in the United States. In 2005, the American Cancer Society estimated that there would be 234,300 new cases of prostate cancer and approximately 30,000 men would die of the disease. Cancer cells differ from normal cells in many ways, including: amplification of proto-oncogenes and the production of growth factors resulting in increased proliferation, loss of differentiation, immortalization, evasion of host immune response and apoptosis, increased invasiveness, loss of contact inhibition and/or the ability to override anti-proliferative signals, loss of tumor suppressor gene expression/function and the ability to sustain angiogenesis. A major focus of cancer biology is the elucidation of the mechanisms by which tumor suppressor and proto-oncogenes are regulated and how they control cell proliferation. The central focus of this dissertation is the characterization of CCAAT/enhancer binding protein delta (C/EBPδ) expression and function in G0 growth arrest in prostate cancer cell biology. Previous studies demonstrated that C/EBPδ, one of the C/EBP family members, plays an important role in regulating growth arrest in mammary epithelial cells. Similarities in the activation of growth arrest pathways between mammary and prostate epithelial cells have been described; however, the function of C/EBPδ in prostate cancer cell biology has not been extensively investigated. The focus of this dissertation was the induction and function of C/EBPδ in prostate cancer cell biology. The purpose of this dissertation was three-fold. First, investigate the induction of C/EBPδ in response to prostate cancer cell growth arrest and determine the signaling pathways required for C/EBPδ induction. Secondly, investigate the potential function of the C/EBPδ growth arrest signaling pathway in prostate cancer progression and metastasis. Finally, identify potential C/EBPδ downstream effector genes to further elucidate the function of C/EBPδ in prostate cancer cell biology.

Indexing (document details)
Advisor: DeWille, James
School: The Ohio State University
Department: Molecular, Cellular, and Developmental Biology
School Location: United States -- Ohio
Source: DAI-B 79/09(E), Dissertation Abstracts International
Subjects: Molecular biology, Cellular biology
Keywords: C/EBP, CCAAT Enhancer Binding Protein, IL-6, Prostate cancer, STAT3
Publication Number: 10835721
ISBN: 978-0-355-96702-9
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