Prostate cancer is the most common cancer among men and the second leading cause of cancer-related mortality in the United States. In 2005, the American Cancer Society estimated that there would be 234,300 new cases of prostate cancer and approximately 30,000 men would die of the disease. Cancer cells differ from normal cells in many ways, including: amplification of proto-oncogenes and the production of growth factors resulting in increased proliferation, loss of differentiation, immortalization, evasion of host immune response and apoptosis, increased invasiveness, loss of contact inhibition and/or the ability to override anti-proliferative signals, loss of tumor suppressor gene expression/function and the ability to sustain angiogenesis. A major focus of cancer biology is the elucidation of the mechanisms by which tumor suppressor and proto-oncogenes are regulated and how they control cell proliferation. The central focus of this dissertation is the characterization of CCAAT/enhancer binding protein delta (C/EBPδ) expression and function in G0 growth arrest in prostate cancer cell biology. Previous studies demonstrated that C/EBPδ, one of the C/EBP family members, plays an important role in regulating growth arrest in mammary epithelial cells. Similarities in the activation of growth arrest pathways between mammary and prostate epithelial cells have been described; however, the function of C/EBPδ in prostate cancer cell biology has not been extensively investigated. The focus of this dissertation was the induction and function of C/EBPδ in prostate cancer cell biology. The purpose of this dissertation was three-fold. First, investigate the induction of C/EBPδ in response to prostate cancer cell growth arrest and determine the signaling pathways required for C/EBPδ induction. Secondly, investigate the potential function of the C/EBPδ growth arrest signaling pathway in prostate cancer progression and metastasis. Finally, identify potential C/EBPδ downstream effector genes to further elucidate the function of C/EBPδ in prostate cancer cell biology.
|School:||The Ohio State University|
|Department:||Molecular, Cellular, and Developmental Biology|
|School Location:||United States -- Ohio|
|Source:||DAI-B 79/09(E), Dissertation Abstracts International|
|Subjects:||Molecular biology, Cellular biology|
|Keywords:||C/EBP, CCAAT Enhancer Binding Protein, IL-6, Prostate cancer, STAT3|
Copyright in each Dissertation and Thesis is retained by the author. All Rights Reserved
The supplemental file or files you are about to download were provided to ProQuest by the author as part of a
dissertation or thesis. The supplemental files are provided "AS IS" without warranty. ProQuest is not responsible for the
content, format or impact on the supplemental file(s) on our system. in some cases, the file type may be unknown or
may be a .exe file. We recommend caution as you open such files.
Copyright of the original materials contained in the supplemental file is retained by the author and your access to the
supplemental files is subject to the ProQuest Terms and Conditions of use.
Depending on the size of the file(s) you are downloading, the system may take some time to download them. Please be