It is not the existence of depressive symptomology, but understanding the function and effect that should be central in how to best support patients. Even in cases of milder depression, phase-of-life issues, or adjustment-related depressive episodes, the myth of a magical pill, here an antidepressant, appeals to the human desire for cessation of whatever unpleasantness may be arising. As a collective, clinicians may be placating clients’ psychological defenses and natural desire to suppress or dissociate at the expense of allowing a soulful opportunity to work through and resolve challenges. Utilizing a primarily hermeneutic approach, the author contemplates various studies supporting psychotherapy, psychopharmacology, and combined therapies. Ultimately, the case is made for decision-making processes that place higher value on the greater context of potential soul opportunities for resolution and healing as well as individuation and growth.