The purpose of this research was to investigate the potential of a laser-based optical polarimetric imaging system, operating under light backscattering geometry, for tumor detection utilizing an optical tumor phantom. Image plays a key role in tumor detection studies. The polarization state of the scattered light from a tumor-like structure and the discrimination of randomly polarized light from weakly polarized light can provide meaningful information regarding the nature of the tumor itself. This information can be both physiological and structural. In this research study, experiments were performed at two optical wavelengths, one visible and one near-infrared wavelength. The weakly scattered light from the tumor tissue like phantom had the necessary information relevant to the structure of the tumor. A Rotating Retarder Polarimeter was used to analyze this weakly scattered light from the phantom. The images obtained from the Rotating Retarder Polarimeter were then processed by means of a data reduction algorithm, based on Polarimetric Measurement matrix method to calculate the Degree of Linear Polarization (DOLP) image. Then, the DOLP images obtained from the two different wavelength lasers were subtracted to enhance the information present in the image.
The Signal-to-Background ratio, a measure of contrast, was calculated to determine the quality of the image. Results from the experiments and the contrast analysis procedures showed that, the subtracted DOLP images provides better contrast in terms of higher numerical value compared to the single DOLP image. Overall, this optical imaging system combined with data reduction algorithm and image processing technique served as an effective imaging methodology in optical tumor phantom study.
|School:||The University of Akron|
|School Location:||United States -- Ohio|
|Source:||MAI 57/05M(E), Masters Abstracts International|
|Keywords:||Dolp, Dolp images, Phantom, Polystyrene, Polystyrene sphere, Subtracted dolp|
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