Dissertation/Thesis Abstract

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Numerical Analysis of Dielectrophoretic Bio-Separation Using Slanted Electrodes
by Kazemi, Bahar, M.S., Southern Illinois University at Edwardsville, 2017, 78; 10686431
Abstract (Summary)

This study presents the numerical simulation and optimization of a dielectrophoretic bio-separation chip for isolating bioparticles such as circulating tumor cells (CTCs), or different strands of E.coli bacteria. The chip consists of ten pairs of slanted electrodes placed with an angle of 10° with respect to the direction of the flow on the top and bottom walls of the channel. The spatially non-uniform electric field produced by the electrodes applies a repulsive force on the particles that are flowing through the channel. The repulsive forces applied by the top and bottom electrodes are balanced and the particles stay at the centerline throughout the channel. The combination of forces in the x and z-directions deflects the particles depending on their size, and guides them towards different outlets. Numerical simulation of the particle-fluid transport was performed using the open-source software OpenFOAM, and the deflection of the particles within the microfluidic channel was predicted. The present computational domain considers the dominant forces such as the dielectrophoretic and hydrodynamic forces as well as their effects on the design and operating parameters. The results show that this device is capable of separating various cells with different sizes from their native environment. Furthermore, a parametric study was performed to investigate the effect of voltage, flow rate, number of electrodes, cell size, and channel height on the separation process and to improve the performance of the device.

Indexing (document details)
Advisor: Darabi, Jeff
Commitee: Molki, Majid, Shavezipour, Mohammad
School: Southern Illinois University at Edwardsville
Department: Mechanical and Industrial Engineering
School Location: United States -- Illinois
Source: MAI 57/04M(E), Masters Abstracts International
Source Type: DISSERTATION
Subjects: Engineering, Mechanical engineering
Keywords: Bio-separation, Dielectrophoresis, Microfluidics, Slanted electrodes
Publication Number: 10686431
ISBN: 9780355611311
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