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This dissertation explores Bayesian nonparametric (BNP) approaches for missing data imputation and causal inference with applications to electronic health records (EHR). The major contribution of the dissertation to the subject is 1) to propose a exible fully BNP model to impute missing covariates (confounders) in regression and comparative effectiveness analysis and further extend the approach to include auxiliary variables while keeping the imputation model always compatible with the inference model; 2) to propose BNP methods to estimate quantile causal effects by exibly modeling the propensity score and the distribution of potential outcomes. The methods developed are applied to a glucose study with missing covariates and a serum creatinine study comparing causal effects of two drug therapies using EHR data.
| Advisor: | Daniels, Michael J. |
| Commitee: | Ghosh, Malay, Presnell, Brett Douglas, Zhang, Lei |
| School: | University of Florida |
| Department: | Statistics |
| School Location: | United States -- Florida |
| Source: | DAI-B 79/04(E), Dissertation Abstracts International |
| Source Type: | DISSERTATION |
| Subjects: | Biostatistics, Statistics |
| Keywords: | Bayesian additive regression trees, auxiliary variables, congenial malels, dirichlet process mixture motifs, multiple imputation, quantile causal effects |
| Publication Number: | 10679207 |
| ISBN: | 978-0-355-40227-8 |
