Natural products from plants have been an important source in drug discovery throughout human history, especially in anticancer drug development. The New Jersey Pine Barrens (NJ pinelands) is a vast wild ecosystem from which little chemical or bioactivity exploration of the plants has been done. In our continuing search for naturally-occurring compounds with interesting biological activities, bioassay-guided fractionation of Leiophyllum buxifolium (sand myrtle) collected from the NJ pinelands, led to the isolation of a new C-methylisoflavone, isosideroxylin. This new compound displayed a selective antiproliferative effect against MDA-MB-231 cells, while showing weak inhibition against the MCF-7 cell line and no inhibition against the normal fibroblast cell line. To prepare for the SAR study and search for more potent analogs, a proof of concept study of the total synthetic route of isosideroxylin starting from phloroglucinol was developed.
|Advisor:||McKee, James R.|
|Commitee:||Fasella, Elisabetta, Jonnalagadda, Kamal, McEwan, Charles N., Tomsho, John W.|
|School:||University of the Sciences in Philadelphia|
|Department:||Chemistry and Biochemistry|
|School Location:||United States -- Pennsylvania|
|Source:||DAI-B 79/04(E), Dissertation Abstracts International|
|Subjects:||Chemistry, Organic chemistry|
|Keywords:||Antiproliferative, Cytotoxicity, New Jersey, Pine Barrens, Sand Myrtle|
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