Dissertation/Thesis Abstract

Synthesis of Bivalent Organothiophosphate Inhibitors and Their Inhibition of Butyrylcholinesterase: Studies towards a Potential Treatment of Cognitive Loss Associated with Alzheimer's Disease
by Tahira, Ambreen, M.S., California State University, Long Beach, 2017, 83; 10636600
Abstract (Summary)

Recently, it has been shown that a decrease in activity of acetylcholinesterase (AChE) in AD patients is compensated by an increase in butyrylcholinesterase (BuChE) activity. Therefore, BuChE also becomes a significant target in the treatment of cognitive loss associated with Alzheimer’s disease. While the majority of drug development so far has centered on AChE inhibitors in order to increase the acetylcholine level in AD patients, the development of specific and potent BuChE inhibitors have also begun to attract attention. We recently synthesized and assayed a library of bisthiophosphates as potential BuChE inhibitors. To evaluate if the analogs were selective for BuChE, their inhibitory properties against both BuChE and AChE were determined.

Indexing (document details)
Advisor: Nakayama, Kensaku
Commitee: Acey, Roger A., Schwans, Jason P.
School: California State University, Long Beach
Department: Chemistry and Biochemistry
School Location: United States -- California
Source: MAI 57/01M(E), Masters Abstracts International
Subjects: Chemistry, Biochemistry, Organic chemistry
Publication Number: 10636600
ISBN: 978-0-355-39803-8
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