Recently, it has been shown that a decrease in activity of acetylcholinesterase (AChE) in AD patients is compensated by an increase in butyrylcholinesterase (BuChE) activity. Therefore, BuChE also becomes a significant target in the treatment of cognitive loss associated with Alzheimer’s disease. While the majority of drug development so far has centered on AChE inhibitors in order to increase the acetylcholine level in AD patients, the development of specific and potent BuChE inhibitors have also begun to attract attention. We recently synthesized and assayed a library of bisthiophosphates as potential BuChE inhibitors. To evaluate if the analogs were selective for BuChE, their inhibitory properties against both BuChE and AChE were determined.
|Commitee:||Acey, Roger A., Schwans, Jason P.|
|School:||California State University, Long Beach|
|Department:||Chemistry and Biochemistry|
|School Location:||United States -- California|
|Source:||MAI 57/01M(E), Masters Abstracts International|
|Subjects:||Chemistry, Biochemistry, Organic chemistry|
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