Dissertation/Thesis Abstract

Synthesis, Characterization and Electrochemistry of the Ruthenium Schiff Base Complex [(Saloph)Ru(NO)Cl]
by Fadamin, Arghavan, M.S., Southern Illinois University at Edwardsville, 2017, 101; 10616856
Abstract (Summary)

The vital role that nitric oxide (NO) plays in vasodilation, neurotransmission, and immune response has been well documented over the years. Specifically, the activation of enzymes that possess heme active sites like guanylate cyclase and cytochrome P450. The ruthenium analogues of these biologically-relevant non-heme Schiff base scaffold are of particular interest as a result of their relative stability. Due to the less labile nature of these compounds when compared to the heme counterparts, a more in depth study of the redox behavior for Ru(saloph)(NO)Cl is possible. The specific aim of this research is that to determine the conditions that favor the nucleophilic attack at the bound NO in Ru-NO none-heme Schiff base scaffold to generate none-heme-HNO species. This research specifically focuses on the electrochemical and spectroelectrochemical investigations and significance of Ru(saloph)(NO)Cl.

We will conduct the reaction studies with LC-MS spectrometry, Cyclic voltammetry, EPR and IR-spectroelectrochemistry to provide a more clear picture of the factors affecting the reaction pathways.

This research specifically focuses on the electrochemical and spectroelectrochemical investigations and significance of Ru(saloph)(NO)Cl. Chapter I talks about the background information. Chapter II discusses the total synthesis of the Ru(saloph)(NO)Cl species. Result and discussions are covered in chapters III along with a specific focus on the reduction chemistry of the title compound by cyclic voltammetry, EPR and IR- spectroelectrochemitry in chapter IV. Last of all, conclusions drawn from this research and future works are described in Chapter V.

Indexing (document details)
Advisor: Shaw, Michael
Commitee: Jones, Myron, Shabestary, Nahid
School: Southern Illinois University at Edwardsville
Department: Chemistry
School Location: United States -- Illinois
Source: MAI 57/01M(E), Masters Abstracts International
Source Type: DISSERTATION
Subjects: Inorganic chemistry, Individual & family studies
Keywords: Cyclic voltammetry, Nitrosyl, Saloph, Schiff base ligand
Publication Number: 10616856
ISBN: 978-0-355-24636-0
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